FDA updates warning on use of anti-psychotic medications during pregnancy.Today I came across a news report on Yahoo news regarding a recent FDA update to the pregnancy section of the label on anti-psychotic drugs. Specifically, the FDA indicates that infants born to mothers who take anti-psychotic drugs during the 3rd trimester are at high risk for developing withdrawal or extrapyramidal symptoms (atypical muscle and motor functioning).
The meta-analysis included 83 different studies with a total of 8,167 substance-using patients and 14,352 non-substance using patients. Note that both samples (substance and non-substance using) were patients with a confirmed diagnosis of a psychotic disorder. The study then compared the age of onset of the condition between the substance vs. non-substance using groups.
The study reported in Pediatrics provides data from over 3,000 children and adolescents attending 3rd, 7th, and 8th grade in Singapore and who were surveyed annually between 2007 and 2009.
A team from Columbia University was interested in examining the link between Inter Pregnancy Interval (e.g., time between pregnancies; IPI) and autism. IPI is important because short intervals between pregnancies (e.g., having kids too close together) is associated with specific physiological factors that have been linked to developmental problems, such as low birth weight, prematurity, etc.
While I was out:1. Closely spaced pregnancies increase risk of autism.A study of over 600,000 siblings conducted by a team at Columbia University suggests that second-born children are at a higher risk for autism the closer in age they are to their older siblings. For example, siblings born within 12 months after their older siblings are over 240% more likely to develop autism than siblings born 3 years after their older siblings. The reference: Cheslack-Postava, K., Liu, K., & Bearman, P. (2011). Closely Spaced Pregnancies Are Associated With Increased Odds of Autism in California Sibling Births PEDIATRICS, 127 (2), 246-253 DOI: 10.1542/peds.2010-2371
By Nestor Lopez-Duran PhD
Hi all, I was unable to update child-psych in January due to some work-related issues, but Im finally back and I will start posting again this week. Im also in discussions with a number of colleagues who will write some guest posts during the upcoming months. Thank you to all the readers who sent emails during the absence and appreciate your support and your patience. See you all tomorrow! Nestor.